Corinne Bachelin

This study shows that MS patient-derived lymphocytes in a chimeric mouse model drive smoldering lesion pathology, impair functional recovery, and alter CNS cell populations and myelination.

This study identifies PAK1 and NF2/Merlin as regulators of actin dynamics in oligodendrocytes, showing their role in myelin formation and expansion.

This paper presents a non-human primate model of optic nerve demyelination that recapitulates key features of MS lesions, showing failed remyelination, axonal degeneration, and visual dysfunction.

The paper examines MS patient macrophages and finds they exhibit a pro-inflammatory transcriptomic and metabolic profile, suggesting intrinsic immune cell memory and potential therapeutic targets.

This study shows that Schwann cells migrate along blood vessels in the demyelinated CNS via Eph/ephrin signaling, avoiding myelin and interacting with ECM components.