Author

Élisabeth Houbron

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:Drosophila· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Hervé SeitziD· 4 shared Sophie MocklyiD· 3 shared Isabelle BusseauiD· 2 shared Delphine M. MuriauxiD· 1 shared Hedi Somaï· 1 shared Nathalie GrosiD· 1 shared Pauline De Sousa· 1 shared Sophia Rafasse· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 17 mutual co-author links

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4 shared papersGenetics

Hervé SeitzORCID

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4 papers

Recent·Most cited

CRISPR-Cas9 repair complexity in Drosophila melanogaster: NHEJ-induced deletions and HDR variability in the bantam microRNA gene

Pauline De Sousa, Élisabeth Houbron, Hervé Seitz, Isabelle Busseau

The paper uses CRISPR-Cas9 to edit the bantam gene in Drosophila, revealing variability in NHEJ-induced deletions and HDR outcomes.

bioRxiv · May 29, 2025 · PreprintGenetics

Evaluation of microRNA variant maturation prior to genome edition

Isabelle Busseau, Sophie Mockly, Élisabeth Houbron, Hedi Somaï, Hervé Seitz

The paper evaluates microRNA variant maturation by assessing Drosha-dependent cleavage efficiency to identify variants that accumulate at wild-type levels.

Biochimie · Jun 27, 2023Peer-reviewedMolecular Biology

Biochemistry-informed design selects potent siRNAs against SARS-CoV-2

Élisabeth Houbron, Sophie Mockly, Sophia Rafasse, Nathalie Gros, Delphine M. Muriaux, Hervé Seitz

This paper designs potent siRNAs against SARS-CoV-2 using biochemistry-informed computational methods, achieving high antiviral activity and variant coverage.

RNA Biology · Jun 4, 2023Peer-reviewedMolecular Biology

A rationalized definition of general tumor suppressor microRNAs excludes miR-34a

Sophie Mockly, Élisabeth Houbron, Hervé Seitz

The paper defines tumor suppressor microRNAs requiring genetic/epigenetic inactivation and anti-tumorigenic activity, finding miR-34a does not meet these criteria.

Nucleic Acids Research · Apr 14, 2022Peer-reviewedGenetics