Human pluripotent stem cell-derived bronchial airway organoids provide insights into differential innate immune and long-term responses to SARS-CoV-2 infection in healthy and COPD.
Lisa Morichon, Jitendriya Swain, Nathalie Gros, Amel Nasri, Florent Foisset, Gaëtan Galisot, Victor Racine, Saïd Assou, ARNAUD AB BOURDIN, John De Vos, Delphine M. Muriaux
This study uses human iPSC-derived bronchial organoids to show SARS-CoV-2 causes prolonged infection, cilia destruction, and differential innate immune responses in healthy and COPD models.
bioRxiv · Jun 30, 2025 · PreprintCell Biology