Hervé Seitz

This study shows miR-202-5p regulates medaka fertility by targeting tead3b and vgll4b in a sex-dependent manner, leading to specific reproductive defects in males and females.

This study identifies TopBP1 condensation inhibitors, showing AZD2858 disrupts ATR signaling and synergizes with chemotherapy in colorectal cancer.

The paper uses CRISPR-Cas9 to edit the bantam gene in Drosophila, revealing variability in NHEJ-induced deletions and HDR outcomes.

The paper identifies a miRNA phenotypic target through de novo analysis in a medaka model, revealing miR-202 regulation of egg production via the Hippo pathway.

The paper evaluates microRNA variant maturation by assessing Drosha-dependent cleavage efficiency to identify variants that accumulate at wild-type levels.

This paper designs potent siRNAs against SARS-CoV-2 using biochemistry-informed computational methods, achieving high antiviral activity and variant coverage.

The paper defines tumor suppressor microRNAs requiring genetic/epigenetic inactivation and anti-tumorigenic activity, finding miR-34a does not meet these criteria.