A. A. Bhopatkar

Cytoplasmic Colocalization of Granulins and TDP-43 Prion-like Domain Involves Electrostatically Driven Coacervation Tuned by the Redox State of Cysteines.

This study shows extracellular granulins colocalize with TDP-43 prion-like domain fragments in neuroblastoma cells and undergo phase separation driven by electrostatic interactions and cysteine redox state.

Are Granulins Copper Sequestering Proteins?

This study investigates whether granulins bind copper ions and finds that GRN-3 and GRN-5 selectively bind Cu(II) under neutral pH, suggesting a potential role in copper sequestration and redox regulation.

Granulins modulate liquid-liquid phase separation and aggregation of TDP-43 C-terminal domain

This study shows GRNs-3 and -5 interact with TDP-43CTD to modulate its aggregation and stress granule formation in vitro, linking PGRN loss to FTLD and ALS.