SAMHD1 Impairs HIV-1 Gene Expression and Reactivation of Viral Latency in CD4+ T-cells
J. M. Antonucci, S. H. Kim, C. St. Gelais, S. Bonifati, O. Buzovetsky, K. Knecht, A. A. Duchon, Y. Xiong, K. M. Musier-Forsyth, L. Wu
This study shows that SAMHD1 suppresses HIV-1 gene expression and reactivation in CD4+ T-cells by binding to the HIV-1 LTR and inhibiting transcription.
bioRxiv · Feb 23, 2018Microbiology