J. M. Antonucci

SAMHD1 Impairs HIV-1 Gene Expression and Reactivation of Viral Latency in CD4+ T-cells

This study shows that SAMHD1 suppresses HIV-1 gene expression and reactivation in CD4+ T-cells by binding to the HIV-1 LTR and inhibiting transcription.

The SAM domain of mouse SAMHD1 is critical for its activation and regulation

This study determines the first crystal structure of full-length mouse SAMHD1 in three nucleotide-bound states, revealing a more complex activation process involving the SAM domain compared to human SAMHD1.