A. A. Pitsillides

Cryogenic non-invasive 3D X-ray phase-contrast imaging of unfixed, intact mouse joints reveals shifting chondrocyte hypertrophy across the endochondral interface

This study uses cryogenic X-ray phase-contrast imaging to analyze cartilage thickness and chondrocyte morphology in mouse joints, revealing differences between osteoarthritis-prone and healthy strains.

The tendon interfascicular basement membrane provides a vascular niche for CD146+ pericyte cell subpopulations

This study identifies CD146+ pericyte subpopulations in the tendon interfascicular basement membrane as a vascular niche involved in tendon structure and function, but not stem cell-like properties.

In silico, in vitro, and in vivo models reveal EPHA2 as a target for decreasing inflammation and pathological endochondral ossification in osteoarthritis.

This study identifies EPHA2 as a therapeutic target for osteoarthritis by showing its inhibition reduces inflammation and pathological endochondral ossification in both in vitro and in vivo models.

A New Straightforward Method for Automated Segmentation of Trabecular Bone from Cortical Bone in Diverse and Challenging Morphologies

This paper introduces an automated method to segment trabecular from cortical bone in microCT images, validated across diverse murine and human specimens.

Bimodal Whole-Mount Imaging Of Tendon Using Confocal Microscopy And X-Ray Micro-Computed Tomography

This paper develops a bimodal imaging technique combining confocal microscopy and x-ray micro-CT to analyze tendon structure in rats and horses, revealing laminin-4 networks and enabling quantitative substructure analysis.

Heterogeneity of proteome dynamics between connective tissue phases of adult tendon

The paper measures protein turnover rates in collagen and glycoprotein phases of rat Achilles tendon using isotope labeling and mass spectrometry, finding significant differences in proteome dynamics between the two ECM phases.

Meniscal and ligament modifications in spontaneous and post-traumatic mouse models of osteoarthritis

This study examines meniscal and ligament changes in two mouse OA models, finding increased mineralisation and chondrogenesis associated with cartilage degeneration.