Author

R. Narcisi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

C. Voskamp· 2 shared G. v. Osch· 2 shared W. Koevoet· 2 shared A. A. Pitsillides· 1 shared A. Chavli· 1 shared F. T. Bekedam· 1 shared G. J. V. M. van Osch· 1 shared L. Anderson· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBioengineering

C. Voskamp

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Senescence during early differentiation reduced the chondrogenic differentiation capacity of mesenchymal progenitor cells

C. Voskamp, W. Koevoet, G. v. Osch, R. Narcisi

This study shows that senescence in mesenchymal stem cells during expansion or early differentiation reduces their ability to form cartilage, but not when induced later in differentiation.

bioRxiv · Mar 9, 2023 · PreprintBioengineering

In silico, in vitro, and in vivo models reveal EPHA2 as a target for decreasing inflammation and pathological endochondral ossification in osteoarthritis.

M. N. Ferrao Blanco, R. Lesage, N. Kops, N. Fahy, F. T. Bekedam, A. Chavli, Y. M. Bastiaansen-Jenniskens, L. Geris, M. G. Chambers, A. A. Pitsillides, R. Narcisi, G. J. V. M. van Osch

This study identifies EPHA2 as a therapeutic target for osteoarthritis by showing its inhibition reduces inflammation and pathological endochondral ossification in both in vitro and in vivo models.

bioRxiv · Jun 12, 2022Pharmacology & Toxicology

TWIST1 controls cellular senescence and energy metabolism in mesenchymal stem cells

C. Voskamp, L. Anderson, W. Koevoet, S. Barnhoorn, P. G. Mastroberardino, G. v. Osch, R. Narcisi

This study shows that TWIST1 regulates senescence and metabolism in human mesenchymal stem cells, with TWIST1 silencing inducing a distinct SASP and metabolic profile compared to irradiation-induced senescence.

bioRxiv · Oct 11, 2020Cell Biology