Author

A. A. Shimpi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:flow cytometry· 1 Research Focus:host-pathogen & immune response· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

C. Fischbach· 3 shared L. A. Estroff· 2 shared M. J. Paszek· 2 shared S. Choi· 2 shared A. Chiou· 1 shared A. Verma· 1 shared D. Dai· 1 shared J. C.-H. Kuo· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCancer Biology

C. Fischbach

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3 papers

Recent·Most cited

Collagen mineralization decreases NK cell-mediated cytotoxicity of breast cancer cells via increased glycocalyx thickness

S. Park, S. Choi, A. A. Shimpi, L. A. Estroff, C. Fischbach, M. J. Paszek

This study shows that collagen mineralization increases NK cell resistance in breast cancer by thickening the tumor cell glycocalyx through enhanced sialylation.

bioRxiv · Jan 20, 2024Cancer Biology

Biofunctional matrix models reveal mineral-dependent mechanoregulation of bone metastatic breast cancer

S. Choi, M. A. Whitman, A. A. Shimpi, N. D. Sempertegui, A. Chiou, J. E. Druso, A. Verma, S. C. Lux, Z. Cheng, M. Paszek, O. Elemento, L. A. Estroff, C. Fischbach

The paper shows that mineralization in bone matrix models inhibits tumor cell proliferation and induces a stem-like phenotype, contradicting the assumption that rigidity promotes metastasis.

bioRxiv · Jun 29, 2022 · PreprintBioengineering

Convergent approaches to delineate the metabolic regulation of tumor invasion by hyaluronic acid biosynthesis

A. A. Shimpi, M. L. Tan, M. Vilkhovoy, D. Dai, L. M. Roberts, J. C.-H. Kuo, L. Huang, J. Varner, M. J. Paszek, C. Fischbach

This study investigates how hyaluronic acid biosynthesis affects metabolic regulation of tumor invasion in breast cancer cells using integrated experimental and computational approaches.

bioRxiv · Jun 8, 2022Cancer Biology