C. Fischbach

Bone mineral density affects tumor growth by shaping microenvironmental heterogeneity

This study shows that bone mineral density influences tumor growth by altering microenvironmental complexity in an organism-dependent manner.

Collagen mineralization decreases NK cell-mediated cytotoxicity of breast cancer cells via increased glycocalyx thickness

This study shows that collagen mineralization increases NK cell resistance in breast cancer by thickening the tumor cell glycocalyx through enhanced sialylation.

Biofunctional matrix models reveal mineral-dependent mechanoregulation of bone metastatic breast cancer

The paper shows that mineralization in bone matrix models inhibits tumor cell proliferation and induces a stem-like phenotype, contradicting the assumption that rigidity promotes metastasis.

Convergent approaches to delineate the metabolic regulation of tumor invasion by hyaluronic acid biosynthesis

This study investigates how hyaluronic acid biosynthesis affects metabolic regulation of tumor invasion in breast cancer cells using integrated experimental and computational approaches.

Mucins form a nanoscale material barrier against immune cell attack

This study investigates how glycocalyx thickness, influenced by mucin properties, affects NK cell-mediated cytotoxicity and suggests strategies to enhance cancer immunotherapy.

IGF2BP2 Promotes Cancer Progression by Degrading the RNA Transcript Encoding a v-ATPase Subunit

The paper shows that IGF2BP2 degradation of ATP6V1A transcript, driven by SIRT1 down-regulation and acetylation, impairs lysosomal function and promotes cancer progression.

Computational 4D-OCM for label-free imaging of collective cell invasion and force-mediated deformations in collagen