Author

M. J. Paszek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Bioengineering· 2 Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:fluorescence / live-cell microscopy· 2 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

M. J. Colville· 5 shared J. C.-H. Kuo· 4 shared L.-T. Huang· 4 shared C. Fischbach· 3 shared S. Park· 3 shared W. R. Zipfel· 3 shared A. A. Shimpi· 2 shared H. L. Reesink· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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5 shared papersBioengineering

M. J. Colville

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Recombinant manufacturing of multispecies biolubricants

M. J. Colville, L.-T. Huang, S. Schmidt, K. J. Chen, K. Vishwanath, J. Su, R. Williams, L. Bonassar, H. L. Reesink, M. J. Paszek

This study develops recombinant lubricin analogs with improved biocompatibility and lubricating properties, demonstrating their tissue binding and joint retention in rats.

bioRxiv · May 5, 2024 · PreprintBioengineering

Bio-orthogonal Glycan Imaging of Culture Cells and Whole Animal C. elegans with Expansion Microscopy

J. C.-H. Kuo, M. J. Colville, M. R. Sorkin, J. L. K. Kuo, L.-T. Huang, D. N. Thornlow, G. M. Beacham, G. Hollopeter, M. P. DeLisa, C. A. Alabi, M. J. Paszek

This paper develops multifunctional reagents for nanoscale imaging of glycans using expansion microscopy, validated in C. elegans and mammalian cells.

bioRxiv · Feb 1, 2024 · PreprintBioengineering

Collagen mineralization decreases NK cell-mediated cytotoxicity of breast cancer cells via increased glycocalyx thickness

S. Park, S. Choi, A. A. Shimpi, L. A. Estroff, C. Fischbach, M. J. Paszek

This study shows that collagen mineralization increases NK cell resistance in breast cancer by thickening the tumor cell glycocalyx through enhanced sialylation.

bioRxiv · Jan 20, 2024Cancer Biology

Glycocalyx dynamics and membrane curvature under cytosolic pressure

J. Gandhi, D. L. Koch, M. J. Paszek

This study models glycocalyx and membrane dynamics under cytosolic pressure, showing how glycocalyx compression and clustering influence membrane curvature and potential adhesive signaling.

bioRxiv · May 14, 2023 · PreprintBiophysics

Convergent approaches to delineate the metabolic regulation of tumor invasion by hyaluronic acid biosynthesis

A. A. Shimpi, M. L. Tan, M. Vilkhovoy, D. Dai, L. M. Roberts, J. C.-H. Kuo, L. Huang, J. Varner, M. J. Paszek, C. Fischbach

This study investigates how hyaluronic acid biosynthesis affects metabolic regulation of tumor invasion in breast cancer cells using integrated experimental and computational approaches.

bioRxiv · Jun 8, 2022Cancer Biology

Mucins form a nanoscale material barrier against immune cell attack

S. Park, M. J. Colville, C. R. Shurer, L.-T. Huang, J. C.-H. Kuo, J. H. Paek, M. C. Goudge, J. Su, M. P. DeLisa, J. Lammerding, W. R. Zipfel, C. Fischbach, H. L. Reesink, M. J. Paszek

This study investigates how glycocalyx thickness, influenced by mucin properties, affects NK cell-mediated cytotoxicity and suggests strategies to enhance cancer immunotherapy.

bioRxiv · Jan 28, 2022 · PreprintBiophysics

Litmus-Body: a Molecularly Targeted Sensor for Cell-Surface pH Measurements

M. C. Goudge, J. C.-H. Kuo, A. E. Metzloff, L.-T. Huang, M. J. Colville, W. R. Zipfel, M. J. Paszek

The paper introduces a molecularly targeted pH sensor called Litmus-body, capable of measuring cell-surface pH with high specificity and sensitivity.

bioRxiv · Oct 10, 2019 · PreprintCell Biology

High-speed device synchronization in optical microscopy with an open-source hardware control platform

M. J. Colville, S. Park, W. R. Zipfel, M. J. Paszek

The paper develops an open-source hardware control platform for high-speed device synchronization in optical microscopy, demonstrating its application in various scanning techniques and reducing synchronization artifacts.

bioRxiv · Jan 29, 2019Biophysics