Automated patch clamp screening of amiloride and 5-N,N-hexamethyleneamiloride (HMA) analogs identifies 6-iodoamiloride as a potent acid-sensing ion channel inhibitor.
R. K. Finol-Urdaneta, J. R. McArthur, A. Aboelela, R. S. Bujaroski, H. H. Majed, A. Rangel, D. J. Adams, M. Ranson, M. J. Kelso, B. J. Buckley
The paper screens amiloride analogs using automated patch-clamp to identify 6-iodoamiloride as a more potent ASIC1 inhibitor than amiloride.
bioRxiv · Mar 12, 2022Pharmacology & Toxicology