Pharmacology & ToxicologybioRxiv
Automated patch clamp screening of amiloride and 5-N,N-hexamethyleneamiloride (HMA) analogs identifies 6-iodoamiloride as a potent acid-sensing ion channel inhibitor.
R. K. Finol-Urdaneta, J. R. McArthur, A. Aboelela…·B. J. Buckley
The paper screens amiloride analogs using automated patch-clamp to identify 6-iodoamiloride as a more potent ASIC1 inhibitor than amiloride.
DOI 10.1021/acs.molpharmaceut.2c01083