Author

J. R. McArthur

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:electrophysiology· 2 Assay:bulk RNA-seq· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

D. J. Adams· 3 shared R. K. Finol-Urdaneta· 3 shared A. Aboelela· 1 shared A. Hing· 1 shared A. Hung· 1 shared A. Prowse· 1 shared A. Rangel· 1 shared A. S. Kristensen· 1 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersPharmacology & Toxicology

D. J. Adams

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cellular Heterogeneity of Pluripotent Stem Cell Derived Cardiomyocyte Grafts is Mechanistically Linked to Treatable Arrhythmias

D. Selvakumar, Z. E. Clayton, A. Prowse, S. Dingwall, J. George, H. Shah, S. Chen, R. D. Hume, L. Tjahjadi, S. Igoor, R. J. P. Skelton, A. Hing, H. Paterson, S. L. Foster, L. Pearson, , J. J. H. Chong

This study identifies arrhythmogenic subpopulations in pluripotent stem cell-derived cardiomyocytes and shows that combination therapy and catheter ablation can reduce engraftment arrhythmias.

bioRxiv · Sep 15, 2022 · PreprintCell Biology

Identification of a sensory neuron Cav2.3 inhibitor within a new superfamily of macro-conotoxins

C. M. Hackney, P. Florez Salcedo, E. Mueller, L. D. Kjelgaard, M. Watkins, L. G. Zachariassen, P. S. Tuelung, J. R. McArthur, D. J. Adams, A. S. Kristensen, B. Olivera, R. K. Finol-Urdaneta, H. Safavi, J. P. Morth, L. Ellgaard

The paper identifies a new macro-conotoxin, Mu8.1, which selectively inhibits Cav2.3 calcium channels in sensory neurons, highlighting its potential as a molecular tool for studying neuronal subclasses.

bioRxiv · Jul 4, 2022Biochemistry

Automated patch clamp screening of amiloride and 5-N,N-hexamethyleneamiloride (HMA) analogs identifies 6-iodoamiloride as a potent acid-sensing ion channel inhibitor.

R. K. Finol-Urdaneta, J. R. McArthur, A. Aboelela, R. S. Bujaroski, H. H. Majed, A. Rangel, D. J. Adams, M. Ranson, M. J. Kelso, B. J. Buckley

The paper screens amiloride analogs using automated patch-clamp to identify 6-iodoamiloride as a more potent ASIC1 inhibitor than amiloride.

bioRxiv · Mar 12, 2022Pharmacology & Toxicology

{micro}-Theraphotoxin-Pn3a inhibition of Cav3.3 channels reveals a novel isoform-selective drug binding site

J. R. McArthur, J. Wen, A. Hung, R. K. Finol-Urdaneta, D. J. Adams

This study identifies Pn3a as a subtype-selective inhibitor of CaV3.3 T-type calcium channels, revealing a novel isoform-specific binding site with therapeutic potential.

bioRxiv · Oct 4, 2021Pharmacology & Toxicology