D. J. Adams

Fate-mapping lymphocyte clones and their progenies from induced antigen-signals identifies temporospatial behaviours of T cells mediating tolerance

This study introduces a novel fate-mapping mouse to track lymphocyte clones and their progenies in response to antigen signals, revealing distinct T cell behaviors in tumor immunity.

Identification of a sensory neuron Cav2.3 inhibitor within a new superfamily of macro-conotoxins

The paper identifies a new macro-conotoxin, Mu8.1, which selectively inhibits Cav2.3 calcium channels in sensory neurons, highlighting its potential as a molecular tool for studying neuronal subclasses.

Automated patch clamp screening of amiloride and 5-N,N-hexamethyleneamiloride (HMA) analogs identifies 6-iodoamiloride as a potent acid-sensing ion channel inhibitor.

The paper screens amiloride analogs using automated patch-clamp to identify 6-iodoamiloride as a more potent ASIC1 inhibitor than amiloride.

Limb Specific Failure of Proliferation and Translation in the Mesenchyme Leads to Skeletal Defects in Diamond Blackfan Anemia

This study identifies site-specific skeletal defects in DBA by showing limb-specific mesenchymal stem cell proliferation and translation failures linked to WNT signaling and p53.

ANTAGONISM OF SAXITOXIN AND TETRODOTOXIN BLOCK BY INTERNAL MONOVALENT CATIONS IN SQUID AXON

This study investigates how internal monovalent cations affect the block of voltage-dependent sodium channels by saxitoxin and tetrodotoxin in squid axons.

{micro}-Theraphotoxin-Pn3a inhibition of Cav3.3 channels reveals a novel isoform-selective drug binding site

This study identifies Pn3a as a subtype-selective inhibitor of CaV3.3 T-type calcium channels, revealing a novel isoform-specific binding site with therapeutic potential.

Fine-mapping of melanoma-associated genomic regions identifies novel causal SNPs in the MTAP/CDKN2A and CASP8 loci

The paper fine-maps melanoma-associated genomic regions to identify novel causal SNPs in the MTAP/CDKN2A and CASP8 loci using sequencing, variant filtering, and functional assays.

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

This study characterizes intra-tumor heterogeneity across 2,658 human cancer genomes, identifying subclonal mutations and evolutionary patterns across 38 cancer types.

Novel gut pathobionts confound results in a widely used mouse model of human inflammatory disease

The paper identifies two novel gut bacteria that influence disease variability in a mouse model of inflammatory bowel disease.

PREDICTIVE IMMUNE CHECKPOINT BLOCKADE CLASSIFIERS DISTINGUISHING MONO- VERSUS COMBINATION THERAPY REQUIREMENT

This paper develops two genetic signatures, InTumor and ExTumor, to predict immune checkpoint blockade response in melanoma patients, enabling stratification for monotherapy or combination therapy.

Tumors induce de novo steroid biosynthesis in T cells to evade immunity

This study shows tumors induce steroid synthesis in T cells to evade immunity, and blocking this pathway restores anti-tumor immunity in mouse models.

A genome-wide screen in mice to identify cell-extrinsic regulators of pulmonary metastatic colonisation

The paper identifies 34 genes that regulate pulmonary metastatic colonisation in mice through a genome-wide screen using mutant mice and metastatic melanoma cells.

Bone marrow stromal cells from a GDF5 origin produce zonal tendon-to-bone attachments following anterior cruciate ligament reconstruction

This study shows that GDF5-origin mesenchymal cells contribute to zonal tendon-to-bone attachments after ACL reconstruction.

In vivo fate of free and encapsulated iron oxide nanoparticles after injection of labelled stem cells

This study compares the in vivo fate of free and encapsulated iron oxide nanoparticles after labeling stem cells, finding both formulations accumulate in liver and spleen and are not fully cleared after two weeks.

Non-invasive imaging reveals conditions that impact distribution and persistence of cells after in vivo administration

The paper uses non-invasive imaging to study how cell type, administration route, and immune status affect the fate and safety of administered human and murine cells in mice.

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

The paper identifies how ATM counteracts toxic non-homologous end-joining at broken replication forks by showing that loss of NHEJ components or BRCA1-A complex confers resistance to DNA-damaging agents in ATM-deficient cells.