A glycerol shunt functions as a glucose excess security valve in pancreatic β-cells
A. Al-Mass, P. Poursharifi, M.-L. Peyot, R. Lussier, E. J. Levens, J. Guida, Y. Mugabo, E. Possik, R. Ahmad, F. Al-Mulla, R. Sladek, S. R. M. Madiraju, M. Prentki
This study identifies a glycerol shunt in pancreatic β-cells that mitigates glucose excess by diverting glucose carbons to glycerol production, thereby preventing insulin hypersecretion and glucotoxicity.
bioRxiv · Nov 20, 2021 · PreprintBiochemistry