Author

R. Sladek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 4 Research Focus:differential expression· 3 Organism:human· 3 Assay:scRNA-seq· 3 Approach:statistical model· 3 Organism:mouse· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

F. Yong· 2 shared G. A. Rutter· 2 shared L. Delgadillo-Silva· 2 shared Y. Ali· 2 shared A. Al-Mass· 1 shared A. Filali-Mouhim· 1 shared A. Kamath· 1 shared A. Kerksiek· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCell Biology

F. Yong

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Comparative proximity biotinylation implicates RAB18 in sterol mobilization and biosynthesis

R. S. Kiss, J. Chicoine, Y. Khalil, R. Sladek, H. Chen, A. Pisaturo, C. Martin, J. D. Dale, T. A. Brudenell, A. Kamath, E. Paci, A. Kerksiek, D. Lütjohann, P. Clayton, J. C. Wills, , M. T. Handley

This study uses proximity biotinylation to identify RAB18 interactors, revealing its role in sterol mobilization and biosynthesis, with implications for Warburg Micro syndrome.

bioRxiv · Feb 27, 2023 · PreprintCell Biology

Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity

V. Yu, F. Yong, A. Marta, S. Khadayate, A. Osakwe, S. Bhattacharya, S. S. Varghese, P. Chabosseau, S. M. Tabibi, K. Chen, E. Georgiadou, N. Parveen, M. Suleiman, Z. Stamoulis, L. Marselli, , S. J. Millership

This study identifies differential CpG methylation at the Nnat gene as a mechanism establishing beta cell heterogeneity during development and its potential role in diabetes.

bioRxiv · Feb 4, 2023Cell Biology

Molecular phenotyping of single pancreatic islet leader beta cells by Flash-Seq

P. Chasbosseau, F. Yong, L. Delgadillo-Silva, E. Young Lee, S. Li, N. Gandhi, J. Wastin, L. Lopez-Noriega, I. Leclerc, Y. Ali, J. HUGHES, R. Sladek, A. Martinez-sanchez, G. A. Rutter

The paper identifies leader beta cells in pancreatic islets using Flash-Seq and finds they have a distinct transcriptome and localization compared to follower cells.

bioRxiv · Aug 26, 2022Cell Biology

Single-cell RNA sequencing reveals a role for reactive oxygen species and peroxiredoxins in fatty-acid-induced rat β-cell proliferation

A. Vivoli, J. Ghislain, A. Filali-Mouhim, Z. E. Angeles, A.-L. Castell, R. Sladek, V. Poitout

This study uses single-cell RNA sequencing to show that oleate induces β-cell proliferation via ROS and peroxiredoxin signaling in rat islets, while palmitate does not.

bioRxiv · Dec 22, 2021Cell Biology

A glycerol shunt functions as a glucose excess security valve in pancreatic β-cells

A. Al-Mass, P. Poursharifi, M.-L. Peyot, R. Lussier, E. J. Levens, J. Guida, Y. Mugabo, E. Possik, R. Ahmad, F. Al-Mulla, R. Sladek, S. R. M. Madiraju, M. Prentki

This study identifies a glycerol shunt in pancreatic β-cells that mitigates glucose excess by diverting glucose carbons to glycerol production, thereby preventing insulin hypersecretion and glucotoxicity.

bioRxiv · Nov 20, 2021 · PreprintBiochemistry