TIM3 is a context-dependent co-regulator of cytotoxic T cell function
H. Alamir, C. W. C. Wong, A. Alsubaiti, G. L. Edmunds, T. Grant, S. Alsulaimani, J. Boyd, C. J. Holland, D. J. Morgan, A. M. Gallimore, C. Wuelfing
This study shows TIM3 inhibits spheroid-suppressed CTL but not active CTL, and its function depends on the context of T cell activation and ligand expression.
bioRxiv · Aug 3, 2023Immunology