Primary saturation of α,β-unsaturated carbonyl containing fatty acids does not abolish electrophilicity
N. W. Snyder, J. O'Brien, B. Singh, G. Buchan, A. D. Arroyo, X. Liu, A. Bostwick, E. L. Varner, A. Angajala, R. W. Sobol, I. A. Blair, C. A. Mesaros, S. G. Wendell
This study investigates the electrophilicity of saturated oxo-fatty acids and finds that mono-saturation retains electrophilicity, while double saturation abolishes it, implicating PTGR1 in their metabolism.
bioRxiv · Sep 24, 2020Biochemistry