Author

S. G. Wendell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:metabolomics· 3 Assay:proteomics· 3 Research Focus:metabolism & bioenergetics· 2 Organism:mouse· 2 Organism:C. elegans· 1

Frequent Co-Authors

N. W. Snyder· 2 shared S. C. Watkins· 2 shared S. J. Mullet· 2 shared A. A. Sims· 1 shared A. Angajala· 1 shared A. Bostwick· 1 shared A. C. Straub· 1 shared A. D. Arroyo· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCell Biology

N. W. Snyder

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A gut commensal protist protects against virus-mediated loss of oral tolerance

M. Siller, Y. Zeng, L. M. Sanchez, P. H. Brigleb, K. A. Sangani, M. Rana, L. Van Der Kraak, S. P. Pandey, M. J. Bender, B. Fitzgerald, L. Hedden, K. Fiske, G. M. Taylor, S. A. Rahman, H. J. Galipeau, , R. Hinterleitner

This study identifies the protist Tritrichomonas arnold as a protector against virus-induced loss of oral tolerance to gluten, showing it reduces inflammation in dendritic cells and is underrepresented in celiac disease patients.

bioRxiv · Jun 21, 2022Immunology

Immunomodulatory actions of a kynurenine-derived endogenous electrophile.

M. Carreno, M. F. Pires, S. R. Woodcock, T. Brzoska, S. Ghosh, S. R. Salvatore, M. Dunn, N. Connors, S. Yuan, A. C. Straub, S. G. Wendell, G. J. Kato, B. A. Freeman, S. Ofori-Acquah, P. Sundd, , D. A. Vitturi

The paper identifies Kyn-CKA as a kynurenine-derived electrophile that reduces inflammation and prevents vaso-occlusion in sickle cell disease.

bioRxiv · Feb 8, 2022Immunology

Persistent DNA damage rewires lipid metabolism and promotes histone hyperacetylation via MYS-1/Tip60.

S. Hamsanathan, T. Anthonymuthu, S. J. Mullet, S. Han, H. Shinglot, E. Siefken, A. A. Sims, P. Sen, H. L. Pepper, S. G. Wendell, N. W. Snyder, H. Bayir, V. E. Kagan, A. U. Gurkar

This study shows persistent DNA damage alters lipid metabolism and histone acetylation via MYS-1/Tip60, leading to immune-like responses and age-related decline.

bioRxiv · Jun 24, 2021Cell Biology

Primary saturation of α,β-unsaturated carbonyl containing fatty acids does not abolish electrophilicity

N. W. Snyder, J. O'Brien, B. Singh, G. Buchan, A. D. Arroyo, X. Liu, A. Bostwick, E. L. Varner, A. Angajala, R. W. Sobol, I. A. Blair, C. A. Mesaros, S. G. Wendell

This study investigates the electrophilicity of saturated oxo-fatty acids and finds that mono-saturation retains electrophilicity, while double saturation abolishes it, implicating PTGR1 in their metabolism.

bioRxiv · Sep 24, 2020Biochemistry

Acetylation-mediated phase control of the nucleolus regulates cellular acetyl-CoA responses

R. Houston, S. Sekine, M. J. Calderon, F. Seifuddin, G. Wang, H. Kawagishi, D. A. Malide, Y. Li, M. Gucek, M. Pirooznia, A. J. Nelson, M. P. Stokes, J. Stewart-Ornstein, S. G. Wendell, S. C. Watkins, , Y. Sekine

The paper shows that acetyl-CoA depletion disrupts nucleolar integrity, activates p53 via ribosomal proteins, and is mediated by class IIa HDACs regulating nucleolar phase state.

bioRxiv · Jan 24, 2020Cell Biology