Author

R. W. Sobol

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Assay:DNA methylation· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

J. Li· 3 shared J. Clark· 2 shared J. F. Andrews· 2 shared N. B. Dey· 2 shared Q. Fang· 2 shared A. Angajala· 1 shared A. Beiser· 1 shared A. Bostwick· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCancer Biology

J. Li

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

TRIP12 governs DNA Polymerase β involvement in DNA damage response and repair

B. Inanc, Q. Fang, J. F. Andrews, X. Zeng, J. Clark, J. Li, N. B. Dey, M. Ibrahim, P. Sykora, Z. Yu, A. Braganza, M. Verheij, J. Jonkers, N. A. Yates, C. Vens, R. W. Sobol

This study identifies TRIP12 as a regulator of DNA polymerase β involvement in DNA damage response and repair by controlling its trafficking and chromatin loading.

bioRxiv · Apr 8, 2024 · PreprintCancer Biology

Deoxyuridine-rich cytoplasmic DNA antagonizes STING-dependent innate immune responses and sensitizes resistant tumors to anti-PD-L1 therapy

P. Pandya, F. P. Vendetti, J. A. El-Ghoubaira, S. Pathak, J. J. Deppas, R. E. Jones, A. V. Columbus, Y. Zhang, D. Ivanov, Z. Huang, K. M. MacDonald, S. M. Harding, R. Buj, K. M. Aird, J. H. Beumer, , C. J. Bakkenist

The paper shows that dU-rich cytoplasmic DNA inhibits STING-dependent immune responses and enhances anti-PD-L1 therapy efficacy in tumors.

bioRxiv · Apr 4, 2024 · PreprintCancer Biology

A high-throughput 384-well CometChip platform reveals a role for 3-methyladenine in the cellular response to etoposide-induced DNA damage

J. Li, A. Beiser, N. B. Dey, S. Takeda, L. K. Saha, K. Hirota, L. L. Parker, M. Carter, M. I. Arrieta, R. W. Sobol

The paper develops a 384-well CometChip platform for high-throughput DNA damage analysis and identifies 3-methyladenine as an enhancer of etoposide-induced DNA damage.

bioRxiv · Mar 29, 2022Cancer Biology

Temporal dynamics of base excision / single-strand break repair protein complex assembly and disassembly are modulated by the PARP1/NAD+/SIRT6 axis

C. A. Koczor, K. M. Saville, J. F. Andrews, J. Clark, Q. Fang, J. Li, M. V. Makarov, M. E. Migaud, R. W. Sobol

The paper investigates the role of the PARP1/NAD+/SIRT6 axis in modulating the assembly and disassembly of DNA repair protein complexes during base excision repair.

bioRxiv · Apr 1, 2021Cancer Biology

Primary saturation of α,β-unsaturated carbonyl containing fatty acids does not abolish electrophilicity

N. W. Snyder, J. O'Brien, B. Singh, G. Buchan, A. D. Arroyo, X. Liu, A. Bostwick, E. L. Varner, A. Angajala, R. W. Sobol, I. A. Blair, C. A. Mesaros, S. G. Wendell

This study investigates the electrophilicity of saturated oxo-fatty acids and finds that mono-saturation retains electrophilicity, while double saturation abolishes it, implicating PTGR1 in their metabolism.

bioRxiv · Sep 24, 2020Biochemistry