Author

M. Osborn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

B. Hanley· 2 shared A. Aivazidis· 1 shared A. Biscans· 1 shared A. Coles· 1 shared A. D. Davidson· 1 shared A. Filby· 1 shared A. Huseynov· 1 shared A. J. Fisher· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersPathology

B. Hanley

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Integrated histopathology, spatial and single cell transcriptomics resolve cellular drivers of early and late alveolar damage in COVID-19

J. T. H. Lee, S. N. Barnett, K. Roberts, H. Ashwin, L. Milross, J.-W. Cho, A. Huseynov, B. Woodhams, A. Aivazidis, T. Li, J. Majo, P. C. Guerrero, M. Lee, A. M. A. Miranda, Z. Jablonska, , O. A. Bayraktar

This study integrates single-cell and spatial transcriptomics with histopathology to identify cellular and molecular changes in lung alveolar damage during COVID-19 progression.

bioRxiv · Dec 20, 2023Pathology

The furin cleavage site of SARS-CoV-2 spike protein is a key determinant for transmission due to enhanced replication in airway cells.

T. P. Peacock, D. H. Goldhill, J. Zhou, L. Baillon, R. Frise, O. C. Swann, R. Kugathasan, R. Penn, J. C. Brown, R. Y. Sanchez-David, L. Braga, M. K. Williamson, J. A. Hassard, E. Staller, B. Hanley, , W. S. Barclay

This study shows the furin cleavage site in SARS-CoV-2 spike protein enhances replication in airway cells, contributing to transmission efficiency.

bioRxiv · Sep 30, 2020 · PreprintMicrobiology

Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo

A. Biscans, A. Coles, R. Haraszti, D. Echeverria, M. Hassler, M. Osborn, A. Khvorova

This study develops lipophilic conjugates to enable siRNA delivery to extra-hepatic tissues, showing effective gene silencing in multiple organs.

bioRxiv · Mar 26, 2018Biochemistry