DNA-binding mechanism and evolution of Replication Protein A
C. Madru, M. Martinez-Carranza, S. Laurent, A. C. Alberti, M. Chevreuil, B. Raynal, A. Haouz, R. A. Le Meur, M. Delarue, D. Flament, M. Krupovic, P. Legrand, L. Sauguet
This study characterizes the DNA-binding mechanism of RPA from Pyrococcus abyssi using crystal and cryo-EM structures, revealing conserved features and a novel archaeal-specific domain.
bioRxiv · Jul 20, 2022Biochemistry