S. Laurent

Inference of evolutionary transitions to self-fertilization using whole-genome sequences

This paper develops two methods to infer the timing of transitions from outcrossing to selfing using whole-genome polymorphism data, applied to Arabidopsis thaliana.

DNA-binding mechanism and evolution of Replication Protein A

This study characterizes the DNA-binding mechanism of RPA from Pyrococcus abyssi using crystal and cryo-EM structures, revealing conserved features and a novel archaeal-specific domain.

Transition to self-compatibility associated with dominant S-allele in a diploid Siberian progenitor of allotetraploid Arabidopsis kamchatica revealed by Arabidopsis lyrata genomes

The paper traces the evolution of self-compatibility in diploid Arabidopsis lyrata and its role in the formation of allotetraploid A. kamchatica through genome analysis.

Gene expression evolution in pattern-triggered immunity within Arabidopsis thaliana and across Brassicaceae species

The paper identifies genes under purifying selection and species-specific expression signatures in PTI responses across Brassicaceae species using comparative transcriptomics.

Direct detection of circulating microRNA-122 using dynamic chemical labelling with single molecule detection overcomes stability and isomiR challenges for biomarker qualification

This paper develops a DCL assay to directly detect miR-122 in serum/plasma, overcoming stability and isomiR challenges for DILI biomarker qualification.

Longitudinally persistent cerebrospinal fluid B-cells resist treatment in multiple sclerosis

This study identifies persistent B-cell clones in the cerebrospinal fluid of MS patients despite treatment, suggesting therapy-resistant immune mechanisms in the central nervous system.

The fitness consequences of genetic variation in wild populations of mice

The paper investigates how genetic variation in wild mice affects fitness by linking genotype to phenotype and allele frequency changes through field and lab experiments.

The demographic history of African Drosophila melanogaster

This paper quantitatively models the demographic history of African Drosophila melanogaster populations, including ancestral Zambian and colonized West African populations.

The evolutionary history of Nebraska deer mice: local adaptation in the face of strong gene flow

This study examines the demographic and selective history of deer mice in Nebraska, finding that gene flow homogenizes most of the genome but the Agouti locus shows local adaptation due to cryptic coloration.

No evidence for the radiation time lag model after whole genome duplications in Teleostei

This study tests the radiation time lag model after whole genome duplications in teleost fishes using fossil data and molecular phylogenies, finding no evidence of delayed evolutionary success.