Orphan nuclear receptor COUP-TFII drives the myofibroblast metabolic shift leading to fibrosis
L. Li, P. Galichon, X. Xiao, A. C. Figueroa-Ramirez, D. Tamayo, J. J. Lee, M. Kalocsay, D. Gonzalez-Sanchez, M. S. Chancay, K. McCracken, D. Lemos, N. Lee, T. Ichimura, Y. Mori, M. T. Valerius, , J. V. Bonventre
This study identifies COUP-TFII as a driver of myofibroblast metabolic shift to aerobic glycolysis, promoting fibrosis in multiple organs.
bioRxiv · Jun 5, 2020 · PreprintCell Biology