Author

A. C. Rothchild

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. Aderem· 3 shared D. Mai· 3 shared A. H. Diercks· 2 shared A. Bhatt· 1 shared A. Jahn· 1 shared A. Kaur· 1 shared C. Cooper· 1 shared E. J. R. Peterson· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersImmunology

A. Aderem

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Exposure to mycobacterium remodels alveolar macrophages and the early innate response to Mycobacterium tuberculosis infection

D. Mai, A. Jahn, T. Murray, M. Morikubo, P. N. Lim, M. M. Cervantes, L. K. Pham, J. C. Nemeth, K. B. Urdahl, A. H. Diercks, A. Aderem, A. C. Rothchild

This study shows that prior exposure to mycobacteria remodels alveolar macrophages, enhancing their pro-inflammatory response to Mtb infection through both intrinsic changes and environmental factors.

bioRxiv · Sep 19, 2022Immunology

Alveolar macrophages up-regulate a non-classical innate response to Mycobacterium tuberculosis infection in vivo

A. C. Rothchild, G. S. Olson, J. Nemeth, L. M. Amon, D. Mai, E. S. Gold, A. H. Diercks, A. Aderem

Alveolar macrophages infected with Mtb in vivo up-regulate an Nrf2-dependent antioxidant response instead of a pro-inflammatory response, impairing bacterial control.

bioRxiv · Mar 18, 2019 · PreprintImmunology

An essential mycolate remodeling program for mycobacterial adaptation in host cells

E. J. R. Peterson, R. Bailo, A. C. Rothchild, M. Arrieta-Ortiz, A. Kaur, M. Pan, D. Mai, C. Cooper, A. Aderem, A. Bhatt, N. Baliga

The paper introduces Path-seq to study MTB transcription in host cells and identifies a mycolate remodeling program regulated by MadR during infection.

Molecular Systems Biology · Mar 4, 2019Peer-reviewedMicrobiology