Author

K. B. Urdahl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 9 Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 8 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

C. R. Plumlee· 7 shared S. B. Cohen· 5 shared B. H. Gern· 4 shared M. Y. Gerner· 4 shared A. Aderem· 2 shared A. H. Diercks· 2 shared C. R. Stoltzfus· 2 shared A. C. Rothchild· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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7 shared papersImmunology

C. R. Plumlee

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

CD4-mediated immunity shapes neutrophil-driven tuberculous pathology

B. H. Gern, J. M. Klas, K. A. Foster, S. B. Cohen, C. R. Plumlee, F. J. Duffy, M. L. Neal, M. Halima, A. T. Gustin, A. H. Diercks, A. Aderem, M. Gale, J. D. Aitchison, M. Y. Gerner, K. B. Urdahl

This study shows that prior immunity influences tuberculosis lesion structure by modulating neutrophil and T cell responses, leading to different pathological outcomes.

bioRxiv · Apr 12, 2024Immunology

Re-appraising the role of T-cell derived interferon gamma in restriction of Mycobacterium tuberculosis in the murine lung

K. Maciag, C. R. Plumlee, S. B. Cohen, B. H. Gern, K. B. Urdahl

This study shows T cell-derived IFN-gamma is critical for controlling Mycobacterium tuberculosis in the murine lung, despite equivalent bacterial burdens in T cell-deficient mice.

bioRxiv · Apr 4, 2024 · PreprintImmunology

Assessing vaccine-mediated protection in an ultra-low dose Mycobacterium tuberculosis murine model

C. R. Plumlee, H. W. Barrett, D. E. Shao, K. A. Lien, L. M. Cross, S. B. Cohen, P. T. Edlefsen, K. B. Urdahl

This study evaluates BCG vaccine efficacy using an ultra-low dose Mtb murine model, showing enhanced protection compared to conventional models.

bioRxiv · Mar 22, 2023 · PreprintMicrobiology

Attenuated Mycobacterium tuberculosis Vaccine Protection in a Low Dose Murine Challenge Model

S. J. Vidal, D. Sellers, J. Yu, S. Wakabayashi, J. Sixsmith, M. Aid, J. Barrett, S. F. Stevens, X. Liu, W. Li, C. R. Plumlee, K. B. Urdahl, A. J. Martinot, D. H. Barouch

This study shows that the live attenuated Mtb vaccine candidate ΔLprG provides better protection than BCG in a low dose murine challenge model, reducing detectable infection and containing it anatomically.

bioRxiv · Mar 17, 2023 · PreprintMicrobiology

Exposure to mycobacterium remodels alveolar macrophages and the early innate response to Mycobacterium tuberculosis infection

D. Mai, A. Jahn, T. Murray, M. Morikubo, P. N. Lim, M. M. Cervantes, L. K. Pham, J. C. Nemeth, K. B. Urdahl, A. H. Diercks, A. Aderem, A. C. Rothchild

This study shows that prior exposure to mycobacteria remodels alveolar macrophages, enhancing their pro-inflammatory response to Mtb infection through both intrinsic changes and environmental factors.

bioRxiv · Sep 19, 2022Immunology

TOLLIP resolves lipid-induced EIF2 signaling in alveolar macrophages for durable Mycobacterium tuberculosis protection.

S. Venkatasubramanian, C. Plumlee, K. Dill-McFarland, G. Pearson, S. B. Cohen, A. Lietzke, S. A. Hinderstein, R. Pryor, S. A. Soleimanpour, M. Altman, K. B. Urdahl, J. A. Shah

This study shows TOLLIP prevents lipid-induced EIF2 activation in alveolar macrophages, which allows Mycobacterium tuberculosis replication and reduces protection.

bioRxiv · Aug 24, 2020 · PreprintImmunology

CytoMAP: a spatial analysis toolbox reveals features of myeloid cell organization in lymphoid tissues

C. R. Stoltzfus, J. Filipek, B. H. Gern, B. E. Olin, J. M. Leal, M. R. Lyons-Cohen, J. Huang, C. L. Paz-Stoltzfus, C. R. Plumlee, T. Pöschinger, K. B. Urdahl, M. Perro, M. Y. Gerner

CytoMAP is a spatial analysis toolbox that identifies cellular networks and tissue organization features in lymphoid tissues using 2D/3D imaging data.

bioRxiv · Nov 21, 2019Immunology

TGFβ restricts T cell function and bacterial control within the tuberculous granuloma

B. Gern, K. N. Adams, C. R. Plumlee, C. R. Stoltzfus, L. Shehata, K. Busman-Sahay, S. G. Hansen, M. K. Axthelm, L. J. Picker, J. D. Estes, K. B. Urdahl, M. Y. Gerner

This study shows that TGFβ suppresses T cell function and bacterial control in tuberculous granulomas by inhibiting IFNγ production in T helper 1 cells.

bioRxiv · Jul 9, 2019Immunology

BCG-induced T cells shape Mycobacterium tuberculosis infection before reducing the bacterial burden

J. L. Delahaye, B. H. Gern, S. B. Cohen, C. R. Plumlee, S. Shafiani, M. Y. Gerner, K. B. Urdahl

This study shows BCG vaccination shifts infected cell types in mice, with T cell activation preceding bacterial burden reduction.

bioRxiv · Apr 4, 2019 · PreprintImmunology