Exposure to mycobacterium remodels alveolar macrophages and the early innate response to Mycobacterium tuberculosis infection
D. Mai, A. Jahn, T. Murray, M. Morikubo, P. N. Lim, M. M. Cervantes, L. K. Pham, J. C. Nemeth, K. B. Urdahl, A. H. Diercks, A. Aderem, A. C. Rothchild
This study shows that prior exposure to mycobacteria remodels alveolar macrophages, enhancing their pro-inflammatory response to Mtb infection through both intrinsic changes and environmental factors.
bioRxiv · Sep 19, 2022Immunology