Author

D. Mai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Evolutionary Biology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 5 Organism:mouse· 5 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Approach:statistical model· 4 Research Focus:cell type annotation· 3 Organism:Drosophila· 3 Research Focus:chromatin & epigenetic regulation· 2

Frequent Co-Authors

A. Aderem· 5 shared A. C. Rothchild· 4 shared A. H. Diercks· 3 shared D. Bachtrog· 3 shared A. Jahn· 2 shared G. S. Olson· 2 shared J. Nemeth· 2 shared K. Chatla· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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5 shared papersImmunology

A. Aderem

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Absence of c-Maf and IL-10 enables Type I IFN enhancement of innate responses to low-dose LPS in alveolar macrophages

P. N. Lim, M. M. Cervantes, L. K. Pham, S. Doherty, A. Tufts, D. Dubey, D. Mai, A. Aderem, A. H. Diercks, A. C. Rothchild

This study shows alveolar macrophages have reduced LPS responses due to low TLR4/CD14 surface expression and lack IL-10 production, which is enhanced by type I IFN.

bioRxiv · May 22, 2024 · PreprintImmunology

Exposure to mycobacterium remodels alveolar macrophages and the early innate response to Mycobacterium tuberculosis infection

D. Mai, A. Jahn, T. Murray, M. Morikubo, P. N. Lim, M. M. Cervantes, L. K. Pham, J. C. Nemeth, K. B. Urdahl, A. H. Diercks, A. Aderem, A. C. Rothchild

This study shows that prior exposure to mycobacteria remodels alveolar macrophages, enhancing their pro-inflammatory response to Mtb infection through both intrinsic changes and environmental factors.

bioRxiv · Sep 19, 2022Immunology

Dynamics and impacts of transposable element proliferation during the Drosophila nasuta species group radiation

K. Wei, D. Mai, K. Chatla, D. Bachtrog

This study analyzes TE proliferation in seven Drosophila species, finding associations between TE insertion frequency, gene expression, and evolutionary dynamics.

bioRxiv · Aug 12, 2021Evolutionary Biology

Neo-sex chromosome evolution shapes sex-dependent asymmetrical introgression barrier

S. Wang, M. J. Nalley, K. Chatla, R. Aldaimalani, A. MacPherson, K. Wei, R. Corbett, D. Mai, D. Bachtrog

This study examines how neo-sex chromosome evolution creates sex-dependent asymmetrical introgression barriers in a hybrid swarm of Drosophila species.

bioRxiv · Jul 13, 2021Evolutionary Biology

Molecular characterization of inversion breakpoints in the Drosophila nasuta species group

D. Mai, D. Bachtrog

The paper characterizes chromosomal inversions in the Drosophila nasuta species group using reference-quality assemblies and ancestral karyotype reconstruction, identifying inversion breakpoints and their association with repeated sequences.

bioRxiv · Jun 1, 2021 · PreprintEvolutionary Biology

Alveolar macrophages up-regulate a non-classical innate response to Mycobacterium tuberculosis infection in vivo

A. C. Rothchild, G. S. Olson, J. Nemeth, L. M. Amon, D. Mai, E. S. Gold, A. H. Diercks, A. Aderem

Alveolar macrophages infected with Mtb in vivo up-regulate an Nrf2-dependent antioxidant response instead of a pro-inflammatory response, impairing bacterial control.

bioRxiv · Mar 18, 2019 · PreprintImmunology

An essential mycolate remodeling program for mycobacterial adaptation in host cells

E. J. R. Peterson, R. Bailo, A. C. Rothchild, M. Arrieta-Ortiz, A. Kaur, M. Pan, D. Mai, C. Cooper, A. Aderem, A. Bhatt, N. Baliga

The paper introduces Path-seq to study MTB transcription in host cells and identifies a mycolate remodeling program regulated by MadR during infection.

Molecular Systems Biology · Mar 4, 2019Peer-reviewedMicrobiology

Latent Mycobacterium tuberculosis infection provides protection for the host by changing the activation state of the innate immune system

J. Nemeth, G. S. Olson, A. Rothchild, A. Jahn, D. Mai, F. Duffy, J. Delahaye, S. Srivatsan, C. Plumlee, K. Urdahl, E. Gold, A. Diercks, A. Aderem

This study shows that latent Mycobacterium tuberculosis infection protects hosts by altering the activation state of the innate immune system in both mice and humans.

bioRxiv · Feb 27, 2019Immunology