Discovery of a AhR flavonoid agonist that counter-regulates ACE2 expression in rodent models of inflammation and attenuates ACE2-SARS-CoV2 interaction in vitro
M. Biagioli, S. Marchiano, R. Roselli, C. Di Giorgio, R. Bellini, M. Bordoni, A. Gidari, S. Sabbatini, D. Francisci, B. Fiorillo, B. Catalanotti, E. Distrutti, A. Carino, A. Zampella, G. Costantino, S. Fiorucci
This study identifies pelargonidin, a flavonoid that reduces ACE2 expression and SARS-CoV2 binding in inflamed colons via AhR activation.
bioRxiv · Feb 24, 2021Pharmacology & Toxicology