S. Marchiano

Bile Acids Serve As Endogenous Antagonists Of The Leukemia Inhibitory Factor (LIF) Receptor in Oncogenesis

The paper shows bile acids, specifically GDCA, inhibit LIFR in gastric cancer, suggesting potential for bile acid-based therapies in LIF-driven oncogenesis.

Next generation sequencing analysis of gastric cancer identifies the leukemia inhibitory factor receptor (LIFR) as a driving factor in gastric cancer progression and as a predictor of poor prognosis

This study identifies LIFR as a key driver in gastric cancer progression and a predictor of poor prognosis through RNA-seq analysis of patient samples.

Prediction and validation of host cleavage targets of SARS-CoV-2 3C like protease

This study predicts and validates host cleavage targets of SARS-CoV-2 3CL protease using bioinformatics and experimental methods, identifying new targets like Obscurin and linking them to cardiac dysfunction in COVID-19.

Pharmacologic Therapy for Engraftment Arrhythmia Induced by Transplantation of Human Cardiomyocytes

This study shows that amiodarone and ivabradine together prevent cardiac death and reduce arrhythmia burden in a porcine model of engraftment arrhythmia after human cardiomyocyte transplantation.

Discovery of a AhR flavonoid agonist that counter-regulates ACE2 expression in rodent models of inflammation and attenuates ACE2-SARS-CoV2 interaction in vitro

This study identifies pelargonidin, a flavonoid that reduces ACE2 expression and SARS-CoV2 binding in inflamed colons via AhR activation.

Analysis of gastric cancer transcriptome allows the identification of histotype specific molecular signatures with prognostic potential

This study identifies histotype-specific molecular signatures in gastric cancer using transcriptomic analysis, finding AQP9, CARD14, and CXCR2 as prognostic markers.

SARS-CoV-2 infects human pluripotent stem cell-derived cardiomyocytes, impairing electrical and mechanical function

This study shows SARS-CoV-2 infects human pluripotent stem cell-derived cardiomyocytes, causing electrical and mechanical dysfunction in cardiac cells.