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5 papers
Recent·Most cited
C. Walker, A. Chandrasekaran, D. Mansour, K. Graham, A. Torres, L. Wang, E. M. Lafer, P. Rangamani, J. Stachowiak
The paper shows that actin-binding proteins forming liquid-like condensates can polymerize and bundle actin filaments, expanding the known set of proteins capable of this function.
bioRxiv · May 4, 2024 · PreprintBiophysics
K. Graham, A. Chandrasekaran, L. Wang, N. Yang, E. M. Lafer, P. Rangamani, J. C. Stachowiak
This study shows that liquid-like condensates containing both actin branching and bundling proteins can modulate the competition between these processes, leading to organized actin structures similar to those in migrating cells.
Proceedings of the National Academy of Sciences · Jan 11, 2024Peer-reviewedBiophysics
A. Chandrasekaran, K. Graham, J. Stachowiak, P. Rangamani
This study uses computational modeling and experiments to show that kinetic trapping of actin filaments in VASP droplets leads to different network architectures like shells and rings.
bioRxiv · May 26, 2023Biophysics
K. D. Graham, A. Chandrasekaran, L. Wang, A. Ladak, E. M. Lafer, P. Rangamani, J. C. Stachowiak
This study shows VASP forms liquid-like droplets that drive actin polymerization and bundling by creating actin-rich rings that transition into linear bundles.
bioRxiv · May 9, 2022Biophysics
A. Chandrasekaran, A. Clarke, P. G. McQueen, H.-Y. Fang, G. A. Papoian, E. Giniger
The paper uses computational simulations to show that Abl activity regulates actin network cohesiveness in axons by modulating Arp2/3 activity.
bioRxiv · Nov 1, 2021Cell Biology