Author

J. Stachowiak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 6 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 2 Assay:imaging· 2 Approach:mechanistic / dynamical model· 2 Approach:microscopy & imaging analysis· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

F. Yuan· 3 shared G. Ashby· 3 shared L. Wang· 3 shared P. Rangamani· 3 shared A. Sangani· 2 shared C. C. Hayden· 2 shared E. M. Lafer· 2 shared K. E. Keng· 2 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBiophysics

F. Yuan

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

A live cell imaging-based assay for tracking particle uptake by clathrin-mediated endocytosis

G. Ashby, K. E. Keng, C. C. Hayden, J. Stachowiak

This paper introduces a live-cell imaging assay using TIRF microscopy to track particle uptake by clathrin-mediated endocytosis and analyzes how particle properties affect uptake efficiency.

bioRxiv · Feb 8, 2024 · PreprintBiophysics

Ubiquitin-driven protein condensation initiates clathrin-mediated endocytosis

F. Yuan, S. Gollapudi, K. Day, G. Ashby, A. Sangani, B. Malady, L. Wang, E. M. Lafer, J. Huibregtse, J. Stachowiak

This paper shows that ubiquitin stabilizes Eps15 condensates, which are essential for clathrin-mediated endocytosis, and that ubiquitylation regulates the dynamics of endocytic assemblies.

bioRxiv · Aug 21, 2023 · PreprintCell Biology

Selective endocytic uptake of targeted liposomes occurs within a narrow range of liposome diameter

G. Ashby, K. E. Keng, C. C. Hayden, S. Gollapudi, J. R. Houser, S. Jamal, J. Stachowiak

The paper uses live-cell imaging to show that liposome diameter, not ligand density, primarily determines their endocytic uptake, with targeting most effective for intermediate-sized liposomes.

bioRxiv · Jul 6, 2023Bioengineering

Lipid droplets as substrates for protein phase separation

A. Kamatar, J. P. K. Bravo, F. Yuan, L. Wang, E. M. Lafer, D. W. Taylor, J. Stachowiak, S. H. Parekh

This study shows that intrinsically disordered proteins can undergo phase separation on lipid droplet surfaces, forming liquid-like protein-rich phases.

bioRxiv · Jun 28, 2023Biophysics

Kinetic trapping organizes actin filaments within liquid-like protein droplets

A. Chandrasekaran, K. Graham, J. Stachowiak, P. Rangamani

This study uses computational modeling and experiments to show that kinetic trapping of actin filaments in VASP droplets leads to different network architectures like shells and rings.

bioRxiv · May 26, 2023Biophysics

The ins and outs of membrane bending by intrinsically disordered proteins

F. Yuan, C. T. Lee, A. Sangani, J. Houser, L. Wang, E. Lafer, P. Rangamani, J. Stachowiak

This study investigates how intrinsically disordered proteins with both repulsive and attractive domains influence membrane curvature based on domain positioning and ionic strength.

bioRxiv · Dec 17, 2022Biophysics

A continuum membrane model predicts curvature sensing by helix insertion

Y. Fu, W. Zeno, J. Stachowiak, M. E. Johnson

The paper develops a continuum membrane model to predict how helix insertion affects curvature sensing in membranes, showing it lowers energy for small vesicles but destabilizes larger ones.

bioRxiv · Apr 22, 2021Biophysics

The role of traction in membrane curvature generation

H. Alimohamadi, R. Vasan, J. E. Hassinger, J. Stachowiak, P. Rangamani

This paper demonstrates how membrane curvature can be used to infer local tractions and shows that different membrane deformations correspond to distinct traction distributions.

bioRxiv · Jun 10, 2018Biophysics