Adult Stem Cell-derived Complete Lung Organoid Models Emulate Lung Disease in COVID-19
C. Tindle, M. Fuller, A. Fonseca, S. Taheri, S.-R. Ibeawuchi, N. Beutler, G. Katkar, A. Claire, V. Castillo, M. Hernandez, H. Russo, J. Duran, L. E. Crotty Alexander, A. Tipps, G. Lin, , S. Das
This study develops a human lung organoid model to emulate COVID-19 pathogenesis, showing proximal airway cells drive viral infection while distal cells drive excessive immune response.
bioRxiv · Oct 17, 2020Cell Biology