Author

S.-R. Ibeawuchi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2

Frequent Co-Authors

P. Ghosh· 5 shared D. Sahoo· 4 shared M. S. Anandachar· 4 shared S. Das· 4 shared A. Fonseca· 3 shared R. Pranadinata· 3 shared C. Tindle· 2 shared G. D. Katkar· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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5 shared papersImmunology

P. Ghosh

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Diverse Gut Pathogens Exploit the Host Engulfment Pathway via a Conserved Mechanism

M. S. Anandachar, S. Roy, S. Sinha, B. Agyekum, S.-R. Ibeawuchi, H. Gementera, A. Amamoto, G. D. Katkar, P. Ghosh

The paper identifies a conserved molecular interface between WxxxE-effector proteins from gut pathogens and the host protein ELMO1, showing how pathogens exploit the host's engulfment pathway.

bioRxiv · Apr 9, 2023Immunology

A Living Organoid Biobank of Crohn's Disease Patients Reveals Molecular Subtypes for Personalized Therapeutics

C. Tindle, G. Katkar, A. Fonseca, S. Taheri, J. Lee, P. Maity, I. Sayed, S.-R. Ibeawuchi, E. Vidales, R. Pranadinata, M. Fuller, D. Stec, M. S. Anandachar, K. Perry, H. Lee, , P. Ghosh

This paper creates a biobank of patient-derived organoids to identify molecular subtypes of Crohn's disease and test subtype-specific therapies.

bioRxiv · Mar 11, 2023Immunology

Coupling of NOD2 to GIV is Required for Bacterial Sensing

G. D. Katkar, M. S. Anandachar, S. Sinha, S.-R. Ibeawuchi, C. R. Espinoza, J. Coates, Y. S. Malhotra, M. Mullick, V. Castillo, D. T. Vo, D. Sahoo, P. Ghosh

This paper identifies GIV as a NOD2-interactor that enhances bacterial sensing and signaling in macrophages, revealing how loss of function in the NOD2 1007fs variant impairs protective immune responses.

bioRxiv · Apr 26, 2022 · PreprintImmunology

The interaction of enteric bacterial effectors with the host engulfment pathway control innate immune responses

I. M. Sayed, S.-R. Ibeawuchi, D. Lie, M. S. Anandachar, R. Pranadinata, M. Raffatellu, S. Das

The paper investigates how WxxxE bacterial effectors interact with ELMO1 to regulate inflammation, showing that ELMO1 differentiates pathogenic from commensal bacteria and enhances inflammatory responses through these interactions.

bioRxiv · Jun 7, 2021Microbiology

Adult Stem Cell-derived Complete Lung Organoid Models Emulate Lung Disease in COVID-19

C. Tindle, M. Fuller, A. Fonseca, S. Taheri, S.-R. Ibeawuchi, N. Beutler, G. Katkar, A. Claire, V. Castillo, M. Hernandez, H. Russo, J. Duran, L. E. Crotty Alexander, A. Tipps, G. Lin, , S. Das

This study develops a human lung organoid model to emulate COVID-19 pathogenesis, showing proximal airway cells drive viral infection while distal cells drive excessive immune response.

bioRxiv · Oct 17, 2020Cell Biology

E-cigarettes compromise the gut barrier and trigger gut inflammation

A. Sharma, J. Lee, A. Fonseca, A. Moshensky, T. Kothari, I. S. Ibrahim, S.-R. Ibeawuchi, R. Pranadinata, J. Ear, D. Sahoo, L. Crotty-Alexander, P. Ghosh, S. Das

This study shows that chronic e-cigarette use damages the gut barrier and causes inflammation, driven by non-nicotine chemicals in e-liquids.

bioRxiv · Jul 29, 2020Immunology