Structural pathway for class III PI 3-kinase activation by the myristoylated GTP-binding pseudokinase VPS15
A. S. I. Cook, M. H. Chen, X. Ren…·J. H. Hurley
This study maps the structural pathway of class III PI 3-kinase activation by showing how N-myristoylation of VPS15 stabilizes the inactive conformation and how GTP binding promotes activation.