Author

A. S. I. Cook

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

J. H. Hurley· 2 shared X. Ren· 2 shared A. Claveras Cabezudo· 1 shared A. T. Iavarone· 1 shared A. Yildiz· 1 shared G. Hummer· 1 shared G. Khuu· 1 shared M. Chen· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

J. H. Hurley

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Author profile →

2 papers

Recent·Most cited

Structural pathway for class III PI 3-kinase activation by the myristoylated GTP-binding pseudokinase VPS15

A. S. I. Cook, M. H. Chen, X. Ren, S. Rao, S. N. Garcia, A. Claveras Cabezudo, A. T. Iavarone, G. Hummer, J. H. Hurley

This study maps the structural pathway of class III PI 3-kinase activation by showing how N-myristoylation of VPS15 stabilizes the inactive conformation and how GTP binding promotes activation.

bioRxiv · Sep 28, 2023Biochemistry

Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex

M. Chen, T. N. Nguyen, X. Ren, G. Khuu, A. S. I. Cook, Y. Zhao, A. Yildiz, M. Lazarou, J. H. Hurley

The paper determines the cryo-EM structure of the human ULK1C core and its complex with PI3KC3-C1, revealing structural changes that suggest a mechanism for autophagy initiation through supercomplex formation.

bioRxiv · Jun 1, 2023Biochemistry