A. T. Iavarone

Structural pathway for class III PI 3-kinase activation by the myristoylated GTP-binding pseudokinase VPS15

This study maps the structural pathway of class III PI 3-kinase activation by showing how N-myristoylation of VPS15 stabilizes the inactive conformation and how GTP binding promotes activation.

Dietary- and host-derived metabolites are used by diverse gut bacteria for anaerobic respiration

The paper identifies gut bacteria that use dietary and host-derived metabolites as electron acceptors in anaerobic respiration, revealing new metabolic pathways and reductase evolution.

Distinct energy-coupling factor transporter subunits enable flavin acquisition and extracytosolic trafficking for extracellular electron transfer in Listeria monocytogenes

This study identifies ECF transporter subunits involved in flavin export for flavinylation in L. monocytogenes and shows their directional transport and genomic distribution.

Chorography and conformational dynamism of the Soluble Human Fibrinogen in solution

This study presents a conformationally dynamic model of soluble human fibrinogen in solution using biophysical methods, revealing internal flexibility and a complex conformational landscape.

Temporal and Spatial Resolution of a Protein Quake that Activates Hydrogen Tunneling in Soybean Lipoxygenase

This study investigates hydrogen tunneling in soybean lipoxygenase using X-ray and deuterium exchange experiments, revealing a protein quake mechanism linked to catalytic activation.

CRISPR-Cas9-mediated knockout of CYP79D1 and CYP79D2 in cassava attenuates toxic cyanogen production

This study uses CRISPR-Cas9 to knockout CYP79D1 and CYP79D2 in cassava, reducing cyanide production and improving food safety.

Lysine methylation shields an intracellular pathogen from ubiquitylation

This study shows that Rickettsia parkeri uses lysine methylation to prevent ubiquitylation of outer membrane proteins, thereby evading host autophagy and enabling pathogenesis.

Mitohormesis reprograms macrophage metabolism to enforce tolerance

This paper shows that mitochondrial stress from mtROS and mtRES triggers mitohormesis in macrophages, leading to tolerance by suppressing proinflammatory gene transcription.

The cryo-electron microscopy structure of the human CDK-activating kinase

This paper determines the cryo-EM structure of human CAK, revealing its architecture and inhibitor binding, which informs therapeutic design.

Protein Corona Composition and Dynamics on Carbon Nanotubes in Blood Plasma and Cerebrospinal Fluid

The paper measures protein corona formation on carbon nanotubes and polystyrene nanoparticles in blood plasma and cerebrospinal fluid, identifying key proteins and interactions driving corona composition and dynamics.

Machine Learning Predicts New Anti-CRISPR Proteins

This paper introduces AcRanker, a machine learning method that predicts new anti-CRISPR proteins from proteomes, identifying two novel candidates through sequence analysis.

Oxidative pathways of deoxyribose and deoxyribonate catabolism

The paper identifies novel oxidative pathways for deoxyribose and deoxyribonate catabolism in bacteria using genome-wide mutant fitness assays and genetic evidence.