C. S. Guy

Fluorinated trehalose analogues for cell surface engineering and imaging of Mycobacterium tuberculosis

This paper develops fluorinated trehalose analogues to label and visualize Mycobacterium tuberculosis, showing their uptake correlates with substrate recognition and enabling pathogen-specific detection.

Phosphatidylserine clustering by membrane receptors triggers LC3-associated phagocytosis.

The paper identifies PS clustering by membrane receptors as a trigger for LC3-associated phagocytosis (LAP), revealing a novel PS-mediated signal transduction mechanism.

Anti-apoptotic BH3-only proteins inhibit Bak

The paper identifies BNIP5 and Bcl-G as anti-apoptotic BH3-only proteins that inhibit Bak activation, preventing apoptosis.

Neuroblastoma formation requires unconventional CD4 T cells and myeloid amino acid metabolism

This study identifies unconventional CD4 T cells and myeloid amino acid metabolism as critical for neuroblastoma formation using a mouse model and spatial transcriptomics.

Structural basis of glycerophosphodiester recognition by the Mycobacterium tuberculosis substrate-binding protein UgpB

This study determines the structure of Mtb UgpB bound to GPC and shows it recognizes other glycerophosphodiesters, enhancing understanding of nutrient scavenging in tuberculosis.

Targeting extracellular glycans: Tuning multimeric boronic acids for pathogen-selective killing of Mycobacterium tuberculosis

This study designs multimeric boronic acids that selectively kill Mycobacterium tuberculosis by targeting its unique extracellular glycans, achieving high selectivity and low cytotoxicity.