The APOBEC3A deaminase drives episodic mutagenesis in cancer cells
M. Petljak, K. Chu, A. Dananberg, E. N. Bergstrom, P. von Morgen, L. Alexandrov, M. R. Stratton, J. Maciejowski
This study shows that APOBEC3A drives episodic mutagenesis in cancer cells by reducing clustered mutations and identifying key enzymes involved in mutation generation.
bioRxiv · Feb 14, 2021 · PreprintCancer Biology