Author

A. Darby

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

D. A. Matthews· 2 shared H. Goldswain· 2 shared J. A. Hiscox· 2 shared J. K. Baillie· 2 shared J. Tree· 2 shared L. Turtle· 2 shared M. G. Semple· 2 shared N. Randle· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

D. A. Matthews

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Arsenophonus symbiosis with louse flies: multiple origins, coevolutionary dynamics, and metabolic significance

J. Rihova, S. Gupta, E. Novakova, A. Darby, V. Hypsa

This study analyzes eleven Arsenophonus strains in louse flies, revealing multiple independent origins of symbiosis and differences in B vitamin synthesis capabilities.

bioRxiv · Jul 13, 2023 · PreprintEvolutionary Biology

Re-inventing pathogen passage for social microbes

T. Dimitriu, W. Souissi, P. Morwool, A. Darby, N. Crickmore, B. Raymond

This study shows that metapopulation selection can prevent social cheating and improve virulence in Bacillus thuringiensis against resistant hosts.

bioRxiv · Aug 4, 2022 · PreprintEvolutionary Biology

Rapid selection of P323L in the SARS-CoV-2 polymerase (NSP12) in humans and non-human primate models and confers a large plaque phenotype

X. Dong, H. Goldswain, R. Penrice-Randal, G. Shawli, T. Prince, M. K. Williamson, N. Randle, B. Jones, F. J. Salguero, J. Tree, Y. Hall, C. Hartley, M. Erdmann, J. Bazire, T. Jearanaiwitayakul, , J. A. Hiscox

The paper tracks the rapid emergence of the P323L mutation in SARS-CoV-2 polymerase in human and non-human primate models, showing it confers a larger plaque phenotype compared to P323.

bioRxiv · Dec 23, 2021 · PreprintMicrobiology

Identification and quantification of SARS-CoV-2 leader subgenomic mRNA gene junctions in nasopharyngeal samples shows phasic transcription in animal models of COVID-19 and dysregulation at later time points that can also be identified in humans

R. Penrice-Randal, H. Goldswain, T. Prince, N. Randle, J. Salguero, J. Tree, E. Vamos, C. Nelson, J. P. Stewart, ISARIC-4C Investigators, COG-UK Consortium, M. G. Semple, J. K. Baillie, P. J. M. Openshaw, L. Turtle, , J. A. Hiscox

The paper identifies and quantifies SARS-CoV-2 leader-TRS-junctions in samples, showing phasic sgmRNA transcription in animal models and dysregulation in humans.

bioRxiv · Mar 3, 2021Microbiology

An increase in atypical petal numbers during a shift to autogamy in a coastal sand verbena and potential evolutionary mechanisms

E. LoPresti, J. Mickley, A. Darby, C. G. Eckert, M. Foisy, C. Girvin, S. Jaeger, K. Toll, A. C. Van Natto, M. G. Weber

This study investigates the evolutionary shift to autogamy in Abronia umbellata and finds that reduced petal numbers correlate with smaller flowers, suggesting selection for smaller size rather than inbreeding or hybridization.

bioRxiv · Jan 3, 2021 · PreprintEvolutionary Biology

Comparative Genomics of Staphylococcus Reveals Determinants of Speciation and Diversification of Antimicrobial Defense.

R. Coates-Brown, J. Moran, P. Pongchaikul, A. Darby, M. J. Horsburgh

This study identifies key orthologous proteins that distinguish Staphylococcus species groups and reveals the role of antimicrobial resistance systems in their diversification.

bioRxiv · Mar 8, 2018Microbiology