T. Prince

SARS-CoV-2 NSP12 associates with the TRiC complex and the P323L substitution is a host adaption.

The paper identifies NSP12's interaction with the TRiC complex and shows the P323L substitution enhances viral adaptation by reducing sensitivity to PP2A perturbations.

SARS-CoV-2 Omicron-B.1.1.529 Variant leads to less severe disease than Pango B and Delta variants strains in a mouse model of severe COVID-19

This study compares the severity of SARS-CoV-2 Omicron-B.1.1.529, Pango B, and Delta variants in a mouse model, finding Omicron causes less severe disease with lower viral load and inflammation.

Rapid selection of P323L in the SARS-CoV-2 polymerase (NSP12) in humans and non-human primate models and confers a large plaque phenotype

The paper tracks the rapid emergence of the P323L mutation in SARS-CoV-2 polymerase in human and non-human primate models, showing it confers a larger plaque phenotype compared to P323.

Antiviral activity of molnupiravir precursor NHC against SARS-CoV-2 Variants of Concern (VOCs) and implications for the therapeutic window and resistance

This study evaluates the antiviral activity of molnupiravir's active metabolite NHC against SARS-CoV-2 variants, finds no resistance after 20 passages, and suggests earlier administration for better efficacy.

SARS-CoV-2 neutralising antibodies in Dogs and Cats in the United Kingdom

This study reports the first large-scale serological survey of SARS-CoV-2 neutralising antibodies in dogs and cats in the UK, finding low prevalence during the second wave of human infections.

Sequence analysis of SARS-CoV-2 in nasopharyngeal samples from patients with COVID-19 illustrates population variation and diverse phenotypes, placing the in vitro growth properties of B.1.1.7 and B.1.351 lineage viruses in context.

The paper analyzes SARS-CoV-2 sequence variation in patient samples and compares the in vitro growth of B.1.1.7 and B.1.351 variants to other isolates, finding no significant difference in growth for B.1.1.7.

Identification and quantification of SARS-CoV-2 leader subgenomic mRNA gene junctions in nasopharyngeal samples shows phasic transcription in animal models of COVID-19 and dysregulation at later time points that can also be identified in humans

The paper identifies and quantifies SARS-CoV-2 leader-TRS-junctions in samples, showing phasic sgmRNA transcription in animal models and dysregulation in humans.

Sequential infection with influenza A virus followed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to more severe disease and encephalitis in a mouse model of COVID-19.

This study shows that sequential infection with influenza A virus followed by SARS-CoV-2 in mice leads to more severe disease and encephalitis compared to single infections.

Evidence of exposure to SARS-CoV-2 in cats and dogs from households in Italy

The paper investigates SARS-CoV-2 exposure in companion animals in Italy, finding that 3.4% of dogs and 3.9% of cats had neutralizing antibodies, with higher prevalence in pets from households with COVID-19 cases.

Methods of inactivation of SARS-CoV-2 for downstream biological assays

This study tests methods to inactivate SARS-CoV-2 for use in lower containment laboratories, finding that heat, detergents, and UV light effectively inactivate the virus.