Author

H. Goldswain

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 2 Assay:whole-genome sequencing· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. A. Hiscox· 5 shared R. Penrice-Randal· 5 shared T. Prince· 4 shared C. Hartley· 3 shared J. K. Baillie· 3 shared L. Turtle· 3 shared M. G. Semple· 3 shared N. Randle· 3 shared

Activity by Year

2021-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersMicrobiology

J. A. Hiscox

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Author profile →

6 papers

Recent·Most cited

Inefficient transmission of African swine fever virus to sentinel pigs from environmental contamination under experimental conditions

A. S. Olesen, L. Lohse, F. Accensi, H. Goldswain, G. J. Belsham, A. Botner, C. Netherton, L. K. Dixon, R. Portugal

This study investigates the risk of African swine fever virus (ASFV) transmission to naive pigs from contaminated environments, finding no transmission despite detectable viral DNA in environmental samples.

bioRxiv · Sep 28, 2023Microbiology

Rapid selection of P323L in the SARS-CoV-2 polymerase (NSP12) in humans and non-human primate models and confers a large plaque phenotype

X. Dong, H. Goldswain, R. Penrice-Randal, G. Shawli, T. Prince, M. K. Williamson, N. Randle, B. Jones, F. J. Salguero, J. Tree, Y. Hall, C. Hartley, M. Erdmann, J. Bazire, T. Jearanaiwitayakul, , J. A. Hiscox

The paper tracks the rapid emergence of the P323L mutation in SARS-CoV-2 polymerase in human and non-human primate models, showing it confers a larger plaque phenotype compared to P323.

bioRxiv · Dec 23, 2021 · PreprintMicrobiology

Antiviral activity of molnupiravir precursor NHC against SARS-CoV-2 Variants of Concern (VOCs) and implications for the therapeutic window and resistance

T. Prince, I. Donovan-Banfield, H. Goldswain, R. Penrice-Randal, C. Hartley, T. Fletcher, S. Khoo, J. A. Hiscox

This study evaluates the antiviral activity of molnupiravir's active metabolite NHC against SARS-CoV-2 variants, finds no resistance after 20 passages, and suggests earlier administration for better efficacy.

bioRxiv · Nov 23, 2021 · PreprintMicrobiology

Mutations that adapt SARS-CoV-2 to mustelid hosts do not increase fitness in the human airway.

J. Zhou, T. P. Peacock, J. C. Brown, D. H. Goldhill, A. M. E. Elrefaey, R. Penrice-Randal, V. M. Cowton, G. De Lorenzo, W. Furnon, W. T. Harvey, R. Kugathasan, R. Frise, L. Baillon, R. Lassauniere, N. Thakur, , W. S. Barclay

The paper identifies spike mutations that adapt SARS-CoV-2 to mustelid hosts and assesses their impact on human infectivity and antigenicity.

bioRxiv · Aug 20, 2021 · PreprintMicrobiology

Sequence analysis of SARS-CoV-2 in nasopharyngeal samples from patients with COVID-19 illustrates population variation and diverse phenotypes, placing the in vitro growth properties of B.1.1.7 and B.1.351 lineage viruses in context.

T. Prince, X. Dong, R. Penrice-Randal, N. Randle, C. Hartley, H. Goldswain, B. Jones, M. G. Semple, J. K. Baillie, P. J. M. Openshaw, L. Turtle, ISARIC4C Investigators, G. Hughes, E. Anderson, E. I. Patterson, , J. A. Hiscox

The paper analyzes SARS-CoV-2 sequence variation in patient samples and compares the in vitro growth of B.1.1.7 and B.1.351 variants to other isolates, finding no significant difference in growth for B.1.1.7.

bioRxiv · Mar 30, 2021 · PreprintMicrobiology

Identification and quantification of SARS-CoV-2 leader subgenomic mRNA gene junctions in nasopharyngeal samples shows phasic transcription in animal models of COVID-19 and dysregulation at later time points that can also be identified in humans

R. Penrice-Randal, H. Goldswain, T. Prince, N. Randle, J. Salguero, J. Tree, E. Vamos, C. Nelson, J. P. Stewart, ISARIC-4C Investigators, COG-UK Consortium, M. G. Semple, J. K. Baillie, P. J. M. Openshaw, L. Turtle, , J. A. Hiscox

The paper identifies and quantifies SARS-CoV-2 leader-TRS-junctions in samples, showing phasic sgmRNA transcription in animal models and dysregulation in humans.

bioRxiv · Mar 3, 2021Microbiology