F. J. Salguero

Mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane: a new indirect mechanism driving tissue necrosis in Mycobacterium ulcerans infection

This study shows mycolactone causes endothelial glycocalyx and basement membrane loss via Sec61-dependent mechanisms, leading to vascular dysfunction and tissue necrosis in Buruli ulcer.

Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model.

This study shows that activating HIF signaling reduces SARS-CoV-2 infection and respiratory symptoms in hamsters by decreasing viral RNA and epithelial damage.

Rapid selection of P323L in the SARS-CoV-2 polymerase (NSP12) in humans and non-human primate models and confers a large plaque phenotype

The paper tracks the rapid emergence of the P323L mutation in SARS-CoV-2 polymerase in human and non-human primate models, showing it confers a larger plaque phenotype compared to P323.

Simultaneous infection with porcine reproductive and respiratory syndrome and influenza viruses abrogates clinical protection induced by live attenuated porcine reproductive and respiratory syndrome vaccination

This study shows that co-infection with PRRSV-2 and H3N2 virus reduces the protective effect of PRRS MLV vaccination against clinical disease.

Intranasal type I interferon treatment is beneficial only when administered before clinical signs onset in the SARS-CoV-2 hamster model

This study shows that intranasal type I interferon treatment is effective only when given before clinical signs onset in a SARS-CoV-2 hamster model, not after symptoms appear.

Sequential delivery of LAIV and SARS-CoV-2 in the ferret model can reduce SARS-CoV-2 shedding and does not result in enhanced lung pathology.

This study shows that administering LAIV before or after SARS-CoV-2 infection in ferrets does not worsen disease and may reduce viral shedding.

mRNA vaccine CVnCoV protects non-human primates from SARS-CoV-2 challenge infection

This study shows that the mRNA vaccine CVnCoV protects non-human primates from SARS-CoV-2 infection and reduces disease severity.

Immunological and pathological outcomes of SARS-CoV-2 challenge after formalin-inactivated vaccine immunisation of ferrets and rhesus macaques

This study evaluates vaccine-enhanced disease in ferrets and rhesus macaques after formalin-inactivated SARS-CoV-2 vaccination, finding mild transient lung pathology but no significant enhancement.

Hamster and ferret experimental infection with intranasal low dose of a single strain of SARS-CoV-2

This study infects hamsters and ferrets with low-dose SARS-CoV-2 to compare disease severity, viral spread, and immune responses between species.

Comparison of Rhesus and Cynomolgus macaques as an authentic model for COVID-19.

This study compares rhesus and cynomolgus macaques as models for mild to moderate COVID-19, showing similar viral replication, immune responses, and histopathology.

Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans

This study generates pig-specific monoclonal antibodies against H1N1pdm09 influenza virus that target human-like HA epitopes and reduce disease severity in pigs.

Macrophage-specific responses to human- and animal-adapted tubercle bacilli reveal pathogen and host factors driving multinucleated cell formation

This study compares macrophage responses to human- and animal-adapted tuberculosis pathogens, identifying factors that drive multinucleated cell formation in bovine macrophages infected with M. bovis.

An alternative AUG codon in segment 5 of the 2009 pandemic influenza A virus is a swine-derived virulence motif

The paper identifies an alternative AUG codon in the 2009 pandemic influenza A virus as a virulence factor contributing to pathogenicity in swine and humans.

Experimental infection of cattle with Mycobacterium tuberculosis isolates shows the attenuation of the human tubercle bacillus for cattle

This study infects cattle with M. tuberculosis isolates to show their attenuation compared to M. bovis and explores biomarkers of disease progression using RNA-Seq.