Author

A. Di Domenico

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Assay:DNA methylation· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

A. Perren· 2 shared I. Marinoni· 2 shared A. Cucciardi· 1 shared A. De Luca· 1 shared A. Jarosch· 1 shared A. Menne· 1 shared B. Sainz· 1 shared C. Cortina Duran· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCancer Biology

A. Perren

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3 papers

Recent·Most cited

LAMC2 marks a tumor-initiating cell population with an aggressive signature in pancreatic cancer

D. Delle Cave, S. Buonaiuto, M. Mangini, B. Sainz, A. Di Domenico, T. Teresa Iavazzo, G. Andolfi, C. Cortina Duran, M. Sevillano, C. Heeschen, V. Colonna, M. Corona, A. Cucciardi, M. Di Guida, E. Batlle, , E. Lonardo

This study identifies LAMC2-positive cells as tumor-initiating cells in pancreatic cancer with aggressive properties and shows that targeting TGF-β signaling inhibits metastasis.

bioRxiv · Mar 24, 2022Cancer Biology

DNA methylation reveals distinct cells of origin for pancreatic neuroendocrine carcinomas (PanNECs) and pancreatic neuroendocrine tumors (PanNETs)

T. Simon, P. Riemer, K. Detjen, A. Di Domenico, F. Bormann, A. Menne, S. Khouja, N. Monje, L. H. Childs, D. Lenze, U. Leser, A. Jarosch, F. Rossner, M. Morkel, N. Bluethgen, , C. Sers

The paper uses DNA methylation analysis to distinguish high-grade PanNECs from other PanNETs, revealing an exocrine cell of origin for PanNECs.

bioRxiv · Jun 12, 2020Cancer Biology

Epigenetic landscape of pancreatic neuroendocrine tumours reveals distinct cells of origin and means of tumour progression

A. Di Domenico, C. P. Pipinikas, R. S. Maire, K. Bräutigam, C. Simillion, M. S. Dettmer, E. Vassella, C. Thirlwell, A. Perren, I. Marinoni

The paper uses DNA methylation profiling to identify cell origins and progression mechanisms in PanNETs, finding distinct epigenetic clusters associated with different cell types and clinical outcomes.

bioRxiv · Apr 8, 2020Cancer Biology