E. Batlle

HYL001, a new potent TGFβ signaling inhibitor that is efficacious against microsatellite stable CRC metastasis in combination with immune checkpoint therapy in mice

This paper describes the development of HYL001, a TGFβ inhibitor that effectively combats microsatellite stable CRC metastasis in mice when combined with immune checkpoint therapy.

Mutant TP53 switches therapeutic vulnerability during gastric cancer progression within Interleukin-6 family cytokines

This study identifies IL6/STAT3 signaling as a therapeutic target for TP53-mutant gastric cancer by showing its role in metastatic progression driven by mutant Trp53.

Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5- colorectal cancer cells

This study identifies mechanical phenotype differences between LGR5+ and LGR5- colorectal cancer cells, linking them to membrane to cortex attachment proteins and metastatic potential.

MmCMS: Mouse models' Consensus Molecular Subtypes of colorectal cancer

The paper develops three methods to classify mouse colorectal cancer models into human CMS subtypes, finding that pathway-level classifiers outperform gene-level ones for accurate subtype identification.

LAMC2 marks a tumor-initiating cell population with an aggressive signature in pancreatic cancer

This study identifies LAMC2-positive cells as tumor-initiating cells in pancreatic cancer with aggressive properties and shows that targeting TGF-β signaling inhibits metastasis.

Modelling biochemical gradients in vitro to control cell compartmentalization in a microengineered 3D model of the intestinal epithelium

The paper develops a 3D in vitro intestinal model with controlled biochemical gradients to study cell compartmentalization and its response to niche factors.

Fibroblast alignment coordinates epithelial migration and maintains intestinal tissue integrity

This study shows that fibroblast alignment enhances directed migration of intestinal epithelia and maintains tissue integrity through physical and biochemical interactions.

A Single-Cell Tumor Immune Atlas for Precision Oncology

The paper creates a single-cell tumor immune atlas using data from 217 patients and 13 cancer types to improve immune cell annotation and spatial mapping for precision oncology.

Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration

This study maps mechanical forces in mouse intestinal organoids, revealing how stress patterns drive crypt folding and cell migration through compartmentalization.