M. Morkel

Reporter-based screening identifies RAS-RAF stabilizing mutations as drivers of resistance to broad-spectrum RAS inhibition in colorectal cancer

High-confidence calling of normal epithelial cells allows identification of a novel stem-like cell state in the colorectal cancer microenvironment

The paper develops CCISM to distinguish cancer cells from normal epithelial cells in single-cell data, identifying a novel stem-like cell state in the colorectal cancer microenvironment.

Robust detection of clinically relevant features in single-cell RNA profiles of patient-matched fresh and formalin-fixed paraffin-embedded (FFPE) lung cancer tissue

The paper compares single-cell RNA sequencing from fresh, cryopreserved, and FFPE lung cancer tissues, finding FFPE tissues can reliably detect clinically relevant features.

Oncogenic signalling is coupled to colorectal cancer cell differentiation state

This study shows oncogenic signalling in colorectal cancer is linked to cell differentiation states through a defined axis, with mutations affecting stemness and differentiation.

The single-cell transcriptional landscape of lung carcinoid tumors

This study uses single-cell RNA sequencing to analyze lung carcinoid tumors, revealing their cellular composition, gene expression profiles, and potential therapeutic targets.

Post-entry, spike-dependent replication advantage of B.1.1.7 and B.1.617.2 over B.1 SARS-CoV-2 in an ACE2-deficient human lung cell line

The paper shows that B.1.1.7 and B.1.617.2 SARS-CoV-2 variants have a replication advantage over B.1 in ACE2-deficient lung cells, suggesting reliance on alternative cellular factors.

Single-cell RNA sequencing reveals distinct tumor microenvironmental patterns in lung adenocarcinoma

The paper uses single-cell RNA sequencing to identify two distinct tumor microenvironmental patterns in lung adenocarcinoma, associated with different prognostic outcomes.

DNA methylation reveals distinct cells of origin for pancreatic neuroendocrine carcinomas (PanNECs) and pancreatic neuroendocrine tumors (PanNETs)

The paper uses DNA methylation analysis to distinguish high-grade PanNECs from other PanNETs, revealing an exocrine cell of origin for PanNECs.

Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer

The paper identifies mitogen-activated protein kinase activity as a driver of cell trajectories in colorectal cancer using single-cell transcriptomics and organoid models.

Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium

The paper investigates how oncogenic KRAS and BRAF differentially activate ERK in colon cancer and intestinal epithelium, revealing cell type-specific effects and novel regulatory mechanisms.

Non-canonical HIF-1 stabilization is essential for intestinal tumorigenesis

This study shows that non-canonical HIF-1 stabilization is crucial for intestinal tumorigenesis, independent of hypoxia, by affecting both epithelial and microenvironmental oncogenic processes.