DNA damage response at telomeres boosts the transcription of SARS-CoV-2 receptor ACE2 during aging
S. Sepe, F. Rossiello, V. Cancila, F. Iannelli, V. Matti, G. Cicio, M. Cabrini, E. Marinelli, B. Alabi, A. di Lillo, A. Di Napoli, J. W. Shay, C. Tripodo, F. d'Adda di Fagagna
This study shows that aging-related telomere shortening and DNA damage response increase ACE2 expression, making elderly individuals more susceptible to SARS-CoV-2 infection.
bioRxiv · Jun 9, 2021Cell Biology