Author

J. W. Shay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Animal Behavior & Cognition· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:behavioral assay· 1 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. Cheng· 1 shared A. di Lillo· 1 shared A. Di Napoli· 1 shared A. J. Eisch· 1 shared A. Ludlow· 1 shared B. Alabi· 1 shared C. S. Guzman· 1 shared C. Tripodo· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCell Biology

A. Cheng

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Author profile →

4 papers

Recent·Most cited

Effects of a 33-ion sequential beam galactic cosmic ray analog on male mouse behavior and evaluation of CDDO-EA as a radiation countermeasure

F. C. Kiffer, K. Luitel, F. H. Tran, R. A. Patel, C. S. Guzman, I. Soler, R. Xiao, J. W. Shay, S. Yun, A. J. Eisch

This study examines the effects of 33-ion galactic cosmic ray analog exposure on male mouse behavior and evaluates CDDO-EA as a potential countermeasure, finding no effect on exploration or anxiety but deficits in social novelty preference.

bioRxiv · Jul 15, 2021Animal Behavior & Cognition

DNA damage response at telomeres boosts the transcription of SARS-CoV-2 receptor ACE2 during aging

S. Sepe, F. Rossiello, V. Cancila, F. Iannelli, V. Matti, G. Cicio, M. Cabrini, E. Marinelli, B. Alabi, A. di Lillo, A. Di Napoli, J. W. Shay, C. Tripodo, F. d'Adda di Fagagna

This study shows that aging-related telomere shortening and DNA damage response increase ACE2 expression, making elderly individuals more susceptible to SARS-CoV-2 infection.

bioRxiv · Jun 9, 2021Cell Biology

A dynamic control of human telomerase holoenzyme

M. Sayed, A. Cheng, G. Yadav, A. Ludlow, J. W. Shay, W. E. Wright, Q.-X. Jiang

The paper demonstrates that human telomerase holoenzymes have fast- and slow-acting catalytic sites that become inactive after two rounds of catalysis, and can be reactivated by intracellular factors.

bioRxiv · Jan 21, 2019 · PreprintCell Biology

Human Lung Epithelial Cells Divide >200 Population Doublings without Engaging a Telomere Maintenance Mechanism

J. W. Shay, J. R. Peters-Hall, J. Min, E. Tedone, S. Sho, S. Siteni, I. Mender

Human lung basal epithelial cells can divide over 200 times without telomere maintenance mechanisms under low stress culture conditions.

bioRxiv · Dec 1, 2018Cell Biology